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KMID : 0355820170380010043
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Korean Journal of Oral Anatomy
2017 Volume.38 No. 1 p.43 ~ p.48
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The expression pattern of FMRP and MAP-lb during tooth development
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Kim Hyun-Jin
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Abstract
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The FMRP {Fragile XMental Retardation Protein) is the FMR-\(Fragile XMental Retardation-1) gene product and a selective RNA-binding molecule as a translation repressor. The lack of FMRP caused by the disorder of FMR-1 gene results in fragile X syndrome (FXS) that exhibits advanced dental maturity. Microtu?bule-associated protein lb (MAP-lb) plays important roles in synapse and neurite development in the nervous system. In a previous study, it was reported that FMRP controls MAP-lb translation during the neural develop?ment. In cultured odontoblasts, a positive immunoreactivity of FMRP was shown in the plasma membrane of the odontoblast cell bodies and at the base of odontoblast cell processes. The immunohistochemical staining of MAP-lb at the bell stage during tooth development was detected in polarized odontoblasts with a decreasing pattern from the tip of the cusp to the cervical region. In carious teeth, MAP-lb was positively expressed in the newly differentiated odontoblast-like cells. Therefore, this review suggests a close relationship between FMRP and MAP-lb during tooth development.
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KEYWORD
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FMRP, MBP-lb, Tooth development
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